مشخصات فنی کمپانی مرک MERCK 109944
PROPERTIES
biological source
synthetic (organic)
Quality Level
100
assay
≥98%
form
film or powder
solid
solubility
water, double-distilled: 50 mM
storage temp.
−20°C
InChI
1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
InChI key
OIURYJWYVIAOCW-PQMKYFCFSA-N
DESCRIPTION
General description
Kifunensine is an alkaloid compound, isolated from the actinomycete Kitasporia kifunensis.
Application
Kifunensine has been used as an inhibitor of mannosidase I in Jurkat T-cells, human embryonic kidney (HEK293T/17) cells and in mouse embryonic fibroblast cells.
Biochem/physiol Actions
Kifunensine is a selective inhibitor of class I glycoprotein-processing α-mannosidases.
Kifunensine suppresses endoplasmic reticulum-associated degradation (ERAD) via the inhibition of endoplasmic reticulum-associated mannosidase activity. It is also a glycosidase inhibitor for Class I CAZy glycosylhydrolase family 47.
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